cIAP-1/HIAP-2 Protein from R&D Systems, a Bio-Techne Brand

Product Specs
ItemcIAP-1/HIAP-2 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number818-IA-050
SpeciesHuman
FormatSupplied as a 0.2 µm filtered solution in HEPES, NaCl, DTT and Glycerol
Quantity50 ug
Molecule NamecIAP-1/HIAP-2
Purity>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 68 kDa, reducing conditions
Theoretical: 72 kDa
Brand/TrademarkR&D Systems, a Bio-Techne Brand
ApplicationsInhibition Activity
Conjugate/Tag/LabelUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human cIAP-1 (HIAP-2) Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening
NCBI Gene AliasesMIHB, API1, RNF48, Hiap-2, cIAP1, c-IAP1, HIAP2
NCBI Full Gene Namebaculoviral IAP repeat containing 2

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residuesCell death & diseaseMay 25, 2017Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Marcion G, et al.

(2) USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimeticsCell death and differentiationSeptember 1, 2015Lee EW, Seong D, Seo J, Jeong M, Lee HK, Song J.

(3) Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicityPloS oneJanuary 1, 2014Guicciardi ME, Werneburg NW, Bronk SF, Franke A, Yagita H, Thomas G, Gores GJ.

(4) IKKε-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase ComplexCell ReportsMarch 28, 2013Alicia Y. Zhou, Rhine R. Shen, Eejung Kim, Ying J. Lock, Ming Xu, Zhijian J. Chen, William C. Hahnimmunoprecipitation from HEK293T cells that were transfected with 3xMyc-TRAF2 for 48 h. Recombinant His-cIAP1(818-IA-050) and His-cIAP2(817-P2-050) were purchased from R&D Systems. Recombinant E1 ubiquitin activating enzyme

(5) Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migrationThe Journal of biological chemistryAugust 17, 2012Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K.

(6) Small molecules destabilize cIAP1 by activating auto-ubiquitylationThe Journal of biological chemistryApril 4, 2008Sekine K, Takubo K, Kikuchi R, Nishimoto M, Kitagawa M, Abe F, Nishikawa K, Tsuruo T, Naito M.

(7) Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligasesJournal of molecular and cellular cardiologyOctober 1, 2006Balasubramanian S, Mani S, Shiraishi H, Johnston RK, Yamane K, Willey CD, Cooper G 4th, Tuxworth WJ, Kuppuswamy D.

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cIAP-1/HIAP-2 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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cIAP-1/HIAP-2 Protein from R&D Systems, a Bio-Techne Brand

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